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Figure 1 Figure 2 2 Stereotactic radiotherapy for brain metastases: key aspects and evolving strategies 2.1 Stereotactic radiotherapy for oligometastatic and multiple brain metastases 2.1.1 SRT in oligometastatic brain disease Supported by evidence from several large randomized controlled trials (RCTs) ( 2.1.1.1 Histological type The aforementioned RCTs comparing SRS and WBRT enrolled patients with mixed histologies, with a predominant representation of nonsmall cell lung cancer brain metastases (NSCLCBM) ( Melanoma brain metastases (MBM) serve as a typical example