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Yes, macrogol laxatives can generally be taken safely with Wegovy, as there is no known direct drug interaction

Measurements of food intake in overnight-fasted mice also showed that the anorectic effect of lixisenatide is reduced compared to exendin-4 (Figure 5D, 5E, 5F)

But researchers are looking beyond neurons to study support cells such as glia and astrocytes that could aid appetite reduction