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10.1016/j.jot.2021.03.003 20.0 20.1 Hassan N, Krieg T, Zinser M, Schrder K, Krger N: An Overview of Scaffolds and Biomaterials for Skin Expansion and Soft Tissue Regeneration: Insights on Zinc and Magnesium as New Potential Key Elements

This process not only reduces transendothelial electrical resistance (TEER) and increases RECs permeability but also further downregulates the expression of ZO-1 and claudins through the nuclear factor-B (NF-B) pathway, resulting in a synergistic effect on BRB disruption (165)

Potential Therapeutic Indications for Systemic Delivery: Immune Modulation: Stabilizing and supporting balanced immune responses Metabolic Enhancement: Assisting in energy balance and lean mass preservation

The increased NAD+ availability supports more efficient ATP (cellular energy) production, potentially translating to better endurance, improved workout performance, and faster recovery between training sessions