Zaugg J, Melhem H, Huang X, Wegner M, Baumann M, Surbek D et al (2020) Gestational diabetes mellitus affects placental iron homeostasis: mechanism and clinical implications
Data are shown as the mean S.E.M (n = 5)
Although the actual mechanisms of MTX-induced liver and kidney damage are unknown, one of the hypotheses is the breakdown in cellular antioxidant defences, which increases the production of reactive oxygen species and nitrogen species, inhibits cytosolic NADP-dependent dehydrogenase and NADP malic enzyme, lowers glutathione (GSH), superoxide dismutase (SOD) and catalase levels and reduces the effectiveness of the antioxidant defence system protecting the cell against reactive oxygen species (Reference Savran, Cicek and Doguc7)
Chemical & Handling Information Type: Synthetic FOXO4-interacting peptide analog Peptide length: Short peptide (exact sequence per specification/lot) Appearance: White to off-white lyophilized powder Specifications Peptide: FOXO4-DRI Amount: 5 mg per vial Form: Lyophilized powder Purity: 99% (HPLC)
