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In contrast to therapies that only act on a single receptor, these medications are known as dual-agonists because they activate two receptors simultaneously

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Similarly, activation of mitochondrial CB 1 Rs with THC resulted in reduced glycolytic activity and lactate production in primary cultured astrocytes (01-days-old), which was hypothesized to contribute to the subsequent impaired neuronal function and altered behavior (e.g., social interaction deficit) in young adult (812-weeks-old) mice (Jimenez-Blasco et al., 2020)

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