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Cells possess TfRs that mediate iron metabolism

Notably, as suggested in an animal model of neuroinflammation induced by ischemic stroke damage known to increase the prevalence of M1 microglia in the brain, pre-treatment with melatonin upregulated the expression of TREM2 while downregulating that of proinflammatory genes in microglia (e.g., inducible nitric oxide synthase) [101], suggesting that melatonin may polarize microglia towards its M2 phenotype

The fact that he is a bariatric surgeon is an added advantage