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The SURPASS-2 trial showing tirzepatide achieving significantly greater HbA1c reduction and weight loss than semaglutide in T2DM patients, and the SURMOUNT trials showing up to 22% average body weight reduction in obese patients, have established tirzepatide as the clinical performance leader in the class

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[DOI] [PMC free article] [PubMed] [Google Scholar] Maulucci G., Pani G., Labate V., Mele M., Panieri E., Papi M., Arcovito G., Galeotti T., De Spirito M