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Furthermore, exenatide has been demonstrated to mitigate mitochondrial oxidative stress, reduce Ca 2 overload, inhibit fission, and close the mitochondrial permeability transition pore (mPTP), collectively preventing cardiomyocyte apoptosis by inhibiting the release of proapoptotic proteins such as cytochrome c and caspase-3 [94]

Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes

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MTNR1B-regulated circadian disruption flattens the testosterone diurnal rhythm reducing the morning testosterone peak that provides the androgenic priming for hypothalamic libido circuitry