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It's estimated that almost 40% of the US population is B12 deficient, ranging from mild deficiencies that can cause weakness, tiredness, mood changes and neurological problems, to significant deficiencies that are associated with anemia, easy bruising, numbness in the fingers and toes, difficult walking, depression, memory loss and dementia

5.3 Addressing translational challenges Despite these promising results, several challenges must be addressed to optimize SFNs clinical application