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Hydration is critical as GLP-1 medications can cause slowed digestion and increase the risk of constipation (Mahase, 2023)

Van Giau et al., 2018)

For stages 1and 2, analysis of variance (ANOVA) was applied using the significance level ( p 0.05), F-statistic, and the coefficient of determination (R 2 ) and the lack-of-fit to assess the relevance of each factor in the fitted models and to evaluate the adequacy of the model fit in each case