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Even when higher doses up to 2,000 mg/day, no adverse reactions have been observed (22, 23) On the other hand, dietary fiber is used by some bacteria in the gut microbiota for butyrate production in two different ways: (I) Direct, where fiber acts as a substrate for bacterial fermentation producing butyrate, (II) Indirect since bifidogenic fibers help to increase the abundance of bifidobacteria, which increase butyrate production indirectly (24)

But they are not practice-changing