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4.4 Sulfur-containing amino acid metabolism and renal protection 4.4.1 Metabolic fate of methionine and cysteine Sulfur-containing amino acids (methionine and cysteine) play critical roles in maintaining redox balance and producing protective gaseous signaling molecules (140)

Unresolved issues were as follows: 1) crosstalk between ferroptosis and other cell death pathways (e.g., pyroptosis) in LN, 2) interplay of iron metabolism with epigenetic regulation in ferroptosis-driven autoimmunity, and 3) development of LN-specific ferroptosis inhibitors and sensitive renal biomarkers for clinical translation (225)

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The different mechanismsGLP-1 receptor agonist versus central nervous system stimulantcan lead to a complex drug interaction profile