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Multi-targets or single-molecule peptides with combined agonistic effects of GIPR, GLP-1R and GCGR have been widely explored

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first discovered plasma intestinal flora-dependent small molecule metabolic spectrum by metabonomics and found that the plasma levels of TMAO and its precursors, choline and betaine, can predict the risk of human cardiovascular disease, thus identifying a novel relationship between intestinal flora and metabolic health ( In this paper, we describe in detail how TMAO promotes the transformation of macrophages to foam cells, which lead to reverse cholesterol transport that inhibits bile acid and sterol metabolism, and at the same time enhances the hyperactivity of platelets, which leads to the formation of atherosclerotic plaques

Fact 13: Online gaming communities provide social support equivalent to in-person groups for 58% of participants in multiplayer environments (Gaming Psychology Research, 2024)