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The proline-rich structure resists breakdown

59 In another study of 105 dogs, a chondroprotective combination (Hyaloral) providing 10 mg hyaluronic acid, 1.1 grams hydrolyzed collagen, 156.3 mg glucosamine, 100 mg chondroitin sulfate, and 50 mg gamma oryzanol per 10 kg body weight per day reduced the risk of developing elbow dysplasia (a type of degenerative joint disease) and slowed progression of the disease compared with no supplementation during 20 months of monitoring

Investigators found that, in intermediate age-related macular degeneration eyes, the area of hyperreflective foci along the retinal pigment epithelium was more predictive of disease progression than drusen volume or intraretinal hyperreflective foci, suggesting the area may serve as a harbinger of focal atrophy formation and may predict where hypertransmission defects form in these particular cases

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