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Beyond engaging canonical hypothalamic and hindbrain networks that control metabolic homeostasis, GLP1RAs recruit a discrete population of Glp1r -expressing neurons in the central amygdala, which selectively suppress the consumption of palatable foods by reducing dopamine release in the nucleus accumbens

HbA1c improvements are typically assessed at 3 months after starting treatment and following each dose escalation

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Follow the injection instructions carefully to minimize irritation, clean the injection site before use, and avoid areas with scars or moles