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The American Association of Clinical Endocrinology's 2022 consensus statement notes that GLP-1 receptor agonists are now first-line pharmacotherapy for obesity in patients who do not have contraindications, given their dual efficacy and cardiovascular data

Research published in the British Journal of Pharmacology demonstrated that molecular conjugation of B12 (specifically the corrin ring structure found in cyanocobalamin) with GLP-1 receptor agonists produced a compound that was not as readily absorbed into the brainstem areas responsible for triggering nausea

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