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LC-MS/MS analysis DIA-NN 1.8 ( was used first to build an in silico library data from the Mouse Reference Proteome ( Feb 2022 version), enabling options FASTA digest for library-free search/library generation, Deep learning based spectra and RTs and IMs prediction

The injectable drug, initially only used as diabetes medication, is the first drug since Saxenda (2014) approved to treat chronic weight management in the 70% of American adults who are obese or overweight

Therefore, evidence for the identification of Nox3 as relevant ROS source in this context is missing

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