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Patients should contact their healthcare provider if gastrointestinal side effects do not improve after 68 weeks at a stable dose, as this may indicate poor tolerance requiring dose adjustment or medication discontinuation

Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 52 print issues and online access $199.00 per year only $3.83 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Nature 577 , 623-624 (2020) doi: References Zhang, B et al

Monitor baseline GH, IGF-1, and sex hormones before and during treatment

This condition is life-threatening and requires immediate medical attention