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Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats
Contrary to this, intraperitoneal administration of GLP-1 agonists does not stimulate vagal afferents 33 , only a small subset of GLP-1R-expressing vagal afferents innervate the intestinal mucosa where GLP-1 cells reside 33,34 , and ablation of vagal GLP-1R neurons doesnt prevent GLP-1Rs satiating effects 35
Obes Surg 34(7):23692374
Expert answers to our most frequently asked questions Tirzepatide is a dual GIP/GLP-1 receptor agonist that simultaneously targets two key hormones
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