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[PMC free article: PMC1397593] [PubMed: 5111288] 500

The first wave of disruption is caused by a sudden loss of blood flow to the brain which can quickly lead to metabolic disturbances, inflammation, oxidative stress, and neuronal death, while the second wave occurs at the reperfusion of oxygenated blood into the affected area, putting oxidative stress on the system

33(1): 87107 Pisano C, Pratesi G, Laccabue D, et al