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Congress opted to permanently authorize the DSNP model in the Bipartisan Budget Act (BBA) of 2018 and directed the Centers for Medicare & Medicaid Services (CMS) to establish a higher minimum standard of Medicare-Medicaid integration under these plans

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The peptide functions as a precision senolytic agent by competing with endogenous FOXO4 for p53 binding, releasing the tumor suppressor protein to trigger apoptosis specifically in cells that have accumulated the senescence-associated secretory phenotype (SASP) markers