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Concurrently, ASD children exhibited elevated levels of inflammatory factors in their blood and increased intestinal permeability, consistent with immune dysregulation and impaired intestinal barrier function resulting from microbial imbalance

Most nonantimicrobial sulfonamides contain neither of these structural features

In addition, higher levels of phosphorylated (active) LKB1 were noted under these conditions in the livers of KO mice but not WT mice (Fig