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The FDA Adverse Event Reporting System (FAERS), a global spontaneous reporting system, provides extensive real-world data to identify AE risk signals ( 2 Materials and methods 2.1 Data source The FAERS, accessible at is a global pharmacovigilance database that records AEs, medication errors, and product quality complaints ( The FAERS database contains 21,035,995 raw AE reports from Q1 2004 to Q2 2024

Its ability to modulate protein folding and enhance cellular quality control mechanisms provides additional protection against prion-induced neurodegeneration [92]

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