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Tangent In clinical trials for semaglutide and liraglutide, patients were excluded from studies if they had a history of suicidal attempts, suicidal behavior within 30 days of screening, a history of depression within two years of screening and diagnosis of any severe mental health disorder, like schizophrenia or bipolar disorder

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Semaglutide does have potential cardiovascular benefits for people with type 2 diabetes, and may well be beneficial for people with a history of heart disease

The compound is also studied in cardiovascular and renal research endpoint contexts