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TH, p = 0.12), n = 3 each cohort/genotype, (1 male and 2 females per cohort/genotype)

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Using similar strategies for upstream positive regulators of GPX4, for example, upregulating SLC7A11 expression via gene therapy, can multi-targetedly enhance the cells overall antioxidant capacity and GSH supply, thereby indirectly supporting and enhancing GPX4 activity (Liao et al., 2024)