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When the conversion of propionyl-CoA to succinyl-CoA in the mitochondria fails due to Vitamin B 12 deficiency, elevated blood levels of methylmalonic acid (MMA) occur

Inhibition of NNMT in adipose tissue led to smaller fat cells and reduced fat mass without affecting appetite or energy expenditure. Kraus et al., Cell Metabolism Enhanced Mitochondrial Energy and Endurance By increasing NAD, 5-Amino-1MQ supports mitochondrial function the energy engines of your cells

What we take from the market as supplements usually have a very low amount of usable Vitamin B12 in them, and the main reason for that is fermentation

[1] These effects are typically dose-dependent, most pronounced during dose escalation, and tend to diminish over time