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Ruhoy noted that the GLP-1 receptors are found in many places (brainstem, hippocampus, throughout the gut, mast cells, T and B lymphocytes, natural killer T cells, T-regulatory cells, macrophages, eosinophils, and neutrophils, pancreas, joints, etc.) Both Kaufman and Ruhoy believe the key may lie in the drugs ability to attach to and stabilize mast cells

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The methionine overload would tend to decrease basal hyperhomocysteinemia rather than cause a further increase in basal hyperhomocysteinemia in patients bearing remethylation defects such as folate deficiency (associated or not with the C677T mutation of the MTHFR gene) (Durand et al, 1997a