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Why it works: Pycnogenol, French maritime pine bark extract, is shown to help the body fight normal aging by supporting vascular health and healthy circulation

For best results, combine supplementation with Vitamin C and other antioxidants that work synergistically to restore glow from within.

Its regulation centers on four interconnected processes: iron metabolism, polyunsaturated fatty acids (PUFA) peroxidation, antioxidant defense failure, and mitochondrial dysfunction ( 2.1 Iron metabolism and ferroptosis Iron is central to ferroptosis, as its redox activity catalyzes the formation of reactive oxygen species (ROS) via Fenton reactions, triggering cellular membranes damage and cell death ( A critical regulator of intracellular iron levels is ferritinophagy, the selective autophagic degradation of ferritin mediated by nuclear receptor coactivator 4 (NCOA4)

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