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Bioactive peptides represent a promising compound category that effectively reduces melanin synthesis with minimal side effects

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In another RDP study, 100 patients with mild to moderate osteoarthritis in the knee were supplemented with 150 mg Pycnogenol per day for three months ( decreased their analgesics consumption, while only 8% in the placebo group reduced the dosage

Although treatment is associated with short-term side effects, such as decreased appetite [46], weight loss, headaches, anxiety [13,46], and sleep problems [47], it also has long-term effects, such as impacting bone health [46,48]