Macrocytic anemia occurs when your body doesnt have enough normal red blood cells, and can cause symptoms including muscle weakness and paresthesias (paresthesias is the technical term for the pins and needles feeling on your skin)
hospitalization required Maintenance of Remission: Immunomodulators (azathioprine, 6-MP, methotrexate) for steroid-dependent or frequently-relapsing disease Biologic monotherapy or combination therapy (biologic + immunomodulator) for moderate-to-severe disease Step-up or top-down approach based on disease severity, patient risk factors, and prior therapy Biologic Therapy Targets: TNF-: Infliximab (IV), adalimumab (SC), certolizumab pegol (SC) IL-12/23: Ustekinumab (IV induction, SC maintenance) Integrin: Vedolizumab (IV) IL-23: Risankizumab (IV induction, SC maintenance) JAK inhibition: Upadacitinib (oral) Surgical Management Surgery is indicated in approximately 7080% of patients with Crohns disease over their lifetime, per StatPearls
Cook completed his surgical training at UPMC Pinnacle, followed by a three-year plastic surgery fellowship at Cleveland Clinic Florida and an elite Hand and Microsurgery fellowship at the University of Miami
This can lead to 1-2 week "out of stock" periods that can be frustrating for researchers who haven't planned ahead
