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Do any of you have any idea how Michelle Obama suddenly lost all this weight at 61, which is also a difficult age for a woman to slim down? The thread, which has now been viewed over 3.2 million times, quickly filled with comments speculating over whether or not Obama is on GLP-1s

Mounjaro (tirzepatide) : A dual agonist targeting both GLP-1 and GIP receptors, approved for type 2 diabetes and showing promise in weight loss

This means that only a small fraction of the drug reaches the bloodstream, necessitating higher doses or special formulations in order to achieve the desired therapeutic effect

As a triple receptor agonist targeting GLP-1R, GIPR, and glucagon receptors simultaneously, it is investigated for how this multi-receptor engagement may influence metabolic signaling differently from dual or single receptor agonists