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Description

These structurally similar impurities might: Act as weak antagonists at one receptor, partially blocking the main compound's effect

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(3) Metformin may also boost GLP-1 release in the gut by hindering bile acid reabsorption and raising bile acid levels, indirectly triggering GLP-1 secretion from L cells

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Lindqvist U, Laurent TC

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While most GLP-1 injections can be stopped abruptly from a safety perspective, the effects on appetite, blood sugar, and weight may return gradually

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