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66 In summary, continued discovery of novel AKT substrates involved in GLUT4 translocation indicates that many but not all of the same effectors are involved in the glucose uptake of different tissues, and further studies should be conducted to identify the molecular mediators in all phases of insulin-stimulated glucose uptake

Mitochondrial membrane potential was evaluated through JC-1 assay on methamphetamine-treated SH-SY5Y cells, where pretreatment with lactoferrin- CAY10603-PLGA showed restoration of mitochondrial membrane potential, demonstrating effective reversal of mitochondrial dysfunction