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In several previously determined enterovirus structures, I site density has been observed and variously interpreted as water (EV-A71, 3VBH) 25 , chlorine (CV-A16, 5C4W) 26 , glycerol (HRV14, 4PDW) 27 and glutamic acid (EV-F3, 5OSN) 7

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In contrast, after administration of DiR-labeled ORI@CPD-Lipo, the DiR fluorescence signals in the orthotopic BxPC-3 tumors were significantly enhanced compared with those of ORI@Lipo (DiR-labeled), and the targeted distribution of ORI@CPD-Lipo (DiR-labeled) into the in situ pancreatic BxPC-3 tumors was significant, especially at 824 h