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doi: 10.1210/jc.2011-2882 131 ChildCJZimmermannAGScottRSCutlerGBBattelinoTBlumWFet al

Se explicara por cambios asociados a la inhibicin de la reabsorcin tubular de Na+que resultan en disminucin de la presin intraglomerular y por tanto de la hiperfiltracin que es uno de los principales mecanismos responsables de la nefropata DM102,104,121

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It should only be administered under strict medical supervisionideally through an institutional review boardapproved trial