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Limitations and perspectives Therapeutic approaches targeting cardiac remodeling reversal, including monoclonal antibodies, peptide-based therapies, and AAV vectors, share similar translational challenges with cardiac regeneration strategies, particularly with respect to delivery efficiency and potential off-target effects

These findings are especially relevant for type 2 diabetes patients, who typically exhibit abnormally high glucagon secretion

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Genetics are predetermined for each person, but without an environmental or lifestyle triggerbe that mold, chemicals, stress, etc.some genetic variants never get expressed or become problematic