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The symptom is most pronounced during weeks 1 to 3 of a new dose, when your gastrointestinal tract is still adjusting to the medication's effect on stomach muscle contractions

Downstream Effects The released growth hormone then circulates to peripheral tissues where it exerts direct effects through binding to growth hormone receptors (GHR), and importantly stimulates the production of insulin-like growth factor 1 (IGF-1), particularly in the liver but also in many other tissues

What insulin resistance feels like As oestrogen declines, cells throughout the body become less responsive to insulin

Some benefitslike fat loss and better sleepcan be maintained with healthy habits, but IGF-1 levels may decline after stopping