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Patient Educ Couns 99(6):926943

Nevertheless, insofar as the physiological, postprandial GLP1 release from L cells is concerned, gutderived GLP1 might not reach the CNS at all, but primarily acts locally in a paracrine fashion, activating GLP1 receptors in the vicinity of the intestinal system (Richards et al., 2014)

GLP-1 and Semaglutide: The Biological Mechanism GLP-1 is a hormone secreted in the gut in response to food intake