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Few human studies have been conducted on the effect of melatonin in the lungs

6 However, unlike SGLT-2i, liraglutide did not significantly reduce the incidence of hospitalization for patients with heart failure, which was a predominant benefit with empagliflozin, 48 although the drug was associated with delayed cardiovascular benefits, possibly due to the modification of progression of atherosclerotic cardiovascular disease

So anything we can do to mitigate that has to be helpful in the long run. There is no instant fix to the supply issues, although these are primarily the result of private prescriptions rather than those on the NHS

The biggest lesson was sticking to the gradual escalation and not rushing it