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Nevertheless, in a forced-swimming mouse model, Meldonium reduced exercise-induced mitochondrial dysfunction, oxidative damage, and apoptosis in cardiac tissue, consistent with cardioprotective potential ( In athletes, prolonged high-intensity exertion may lead to athletic heart syndrome, characterized by cardiac hypertrophy, inflammation, oxidative stress, mitochondrial dysfunction, and accumulation of acylcarnitines with disturbed substrate oxidation ( -oxidation and activating glucose-metabolic pathways (e.g., 6-phosphofructokinase and pyruvate dehydrogenase), Meldonium shifts ATP production from lipids toward carbohydrates during exercise, which may reduce oxidative stress and improve metabolic flexibility (32)

Patients following such a diet, should be advised to take oral vitamin B 12 regularly

Alternatively, reach out online or head in-store across, and our friendly ASN team can help you choose the best products to support your individual needs

Meanwhile, weight loss drugs and incretin mimetics like Ozempic (semaglutide), Wegovy, and Mounjaro, introduced in the UK to reduce gastric band surgery, offer rapid results but risk muscle loss and bone density issues