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Physiol Rev 1983;63(4):1420-80

The standard dose for atrial fibrillation is 5 mg twice daily, though this is reduced to 2.5 mg twice daily in patients meeting at least two of the following criteria: age 80 years, body weight 60 kg, or serum creatinine 133 micromol/L

Notably, GHK-Cu levels in circulation are known to decline with age, a pattern that has fueled substantial research interest in the peptide's potential relevance to tissue aging and regenerative capacity over the lifespan

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