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Neuroscience 129(4): 10211029

CagriSema Storage & Handling Storage Reference Lyophilized (powder form) Cagrilintide -4F (-20C) long-term Semaglutide -4F (-20C) long-term Pre-blended CagriSema -4F (-20C) long-term Reconstituted (liquid form) Cagrilintide 35.646.4F (28C) Semaglutide 35.646.4F (28C) Pre-blended CagriSema 35.646.4F (28C) Appearance Cagrilintide Clear after reconstitution Semaglutide Clear after reconstitution Pre-blended CagriSema Clear after reconstitution Stability window after reconstitution Cagrilintide Up to ~28 days refrigerated Semaglutide Up to ~28 days refrigerated Pre-blended CagriSema Per supplier COA Always defer to the supplier's specific stability window

With DSIP nasal spray, peptides bypass the delays of other methods and are efficiently absorbed through the nasal mucosa