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Those homozygous have only ~30% normal enzyme activity. Methylfolate bypasses the problem

doi:103390/nu9040324

For a deeper guide on B12, methylation, and how MTHFR affects what form of folate you should take, my book "Don't B12 Deficient" walks through it

This can damage or destroy insulin receptors and increase the risk of type 2 diabetes ( Animal studies show that NAC may stabilize blood sugar by decreasing inflammation in fat cells and thereby improving insulin resistance ( When insulin receptors are intact and healthy, they properly remove sugar from your blood, keeping levels within normal limits