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GLP-1 RAs are particularly effective for promoting weight loss, controlling glycemic levels (notably A1c), and reducing the risk of strokes

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To prevent movement contamination from confounding the result with 18 F-FDG uptake in muscles, isoflurane anesthesia (5% for induction and 2% for maintenance) was used here for biodistribution detection and imaging

this allow the molecule to get into the body but bypasses the gut