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This change, suggested by an international panel, has garnered widespread support, with numerous studies across the United States, Europe, and Asia providing substantial evidence of the superiority of MAFLD criteria over NAFLD criteria in various aspects of fatty liver diseases (2)

These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients

Caponetti AG, Rapezzi C, Gagliardi C, Milandri A, Dispenzieri A, Kristen AV, Wixner J, Maurer MS, Garcia-Pavia P, Tournev I, et al