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These trials encompass studies of both NRF2 activators and inhibitors in diverse application contexts, including treatments for different diseases, research strategies, and clinical trial phases

To determine whether reducing either or both sources of serine affects carboplatin efficacy in vivo, we injected NCI-H520 cells into the flanks of athymic, immunodeficient mice and fed them either complete amino acid-based diet (Ctrl diet), a high-serine diet (High S diet), a serine-deficient diet (-S diet) or a serine and glycine-deficient diet (-SG diet)

Of course, novel therapeutic strategies based on ROS mechanisms are not limited to antioxidant strategies