While there is no definitive cure for migraines, an array of treatments exists that can help control and manage symptoms effectively
For CNS-targeted research specifically, topical delivery remains largely impractical because the compound must still reach the brain after crossing the skina double barrier problem
Sikiric P1, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Aralica G, Safic H, Suran J, Rak D, Dzidic S, Vrcic H, Sebecic B
These tetrapeptides exhibit antifungal activity akin to alpha-melanocyte-stimulating hormone (-MSH), and theoretical calculations have elucidated their biologically relevant conformation and minimal structural requirements for antifungal response, guiding future compound design