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The most frequently reported side effects are localized and temporary

For instance, in April 2025, Pfizer, a US-based pharmaceutical company specializing in metabolic and cardiometabolic drug development, provided an update on its oral GLP-1 receptor agonist candidate, danuglipron, following the completion of once-daily formulation studies intended to improve dosing convenience for patients

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The median BMI at baseline was 37.3 (IQR, 33.1-42.7), with 45 751 patients (36.5%) overall classified as having class 3 obesity (BMI 40)