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It was previously reported that at physiological pH, the spontaneous reaction between formaldehyde and l-cysteine to form T4C is rapid and chemically favored (31) and that l-cysteine is immediately directed toward the formation of thiazolidines when these two compounds are added to isolated rat liver homogenate (37), consequently scavenging the toxicity of formaldehyde (38)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Edmonds K

GSH itself is known as a major reservoir of non-protein reduced sulfur for the chelation of heavy metal ions and as a precursor of phytochelatin (PC), which is a typical metal chelator found in plants that facilitates metal sequestration into vacuoles ( Arabidopsis thaliana mutants ( E