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This shift is forcing traditional drugmakers to re-evaluate their go-to-market models and is creating a new strategic imperative around the use of sophisticated patent intelligence

With the advancements in single-cell and spatial transcriptomics, understanding the role of clonal evolution and tumor heterogeneity in drug resistance mechanisms is much easier (197)

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The effector T cells can be additionally partitioned into distinct subsets according to their cytokine profiles and genetic expression patterns